Description

(2S, 4R)-4-Amino-1-Benzyloxycarbonyl-Pyrrolidine-2-Carboxylic Acid-Methyl Ester Hydrochloride is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for the development of novel pharmaceuticals, particularly in the creation of peptidomimetics and protease inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry and process development for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, especially protease inhibitors and other bioactive molecules.
• Peptidomimetic Research: Used in the design and construction of peptide analogs to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective reactions to introduce the (2S, 4R) configuration.
• API Development: Integral in the research and scale-up phases for new active pharmaceutical ingredients requiring this specific pyrrolidine scaffold.
• Chemical Biology Probes: Useful for creating labeled compounds or probes to study biological pathways and enzyme functions.
• Custom Synthesis: Serves as a foundational block for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	(2S, 4R)-4-Amino-1-Benzyloxycarbonyl-Pyrrolidine-2-Carboxylic Acid-Methyl Ester Hydrochloride
CAS No.	409325-33-3
Molecular Formula	C15H21ClN2O4
Molecular Weight	328.79 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-amino-(2S,4R)-2-pyrrolidinecarboxylic acid methyl ester hydrochloride; Cbz-4-Amino-(2S,4R)-proline methyl ester hydrochloride; Methyl (2S,4R)-4-amino-1-[(benzyloxy)carbonyl]-2-pyrrolidinecarboxylate hydrochloride; (2S,4R)-4-Amino-1-Cbz-pyrrolidine-2-carboxylic acid methyl ester HCl; (2S,4R)-1-(Benzyloxycarbonyl)-4-aminopyrrolidine-2-carboxylic acid methyl ester hydrochloride; (2S,4R)-1-Cbz-4-aminopyrrolidine-2-carboxylic acid methyl ester hydrochloride; Z-4-Amino-(2S,4R)-Pro-OMe.HCl
EINECS	Contact for details

Quality Control

Our production of (2S, 4R)-4-Amino-1-Benzyloxycarbonyl-Pyrrolidine-2-Carboxylic Acid-Methyl Ester Hydrochloride adheres to stringent quality management protocols. Each batch is characterized and tested to ensure high chemical purity and stereochemical integrity, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.