Description

5'-Trifluoromethyl-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique bipyridinyl scaffold with a trifluoromethyl substituent. This compound is critical for medicinal chemistry research and development, offering significant value in modulating the pharmacokinetic and metabolic properties of drug candidates. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its trifluoromethyl group, which enhances metabolic stability and lipophilicity.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation herbicides and pesticides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological targets and pathways.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs/CMOs).

Basic Information

Product Name	5'-Trifluoromethyl-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-4-Carboxylic Acid
CAS No.	406476-31-1
Molecular Formula	C12H13F3N2O2
Molecular Weight	274.24 g/mol
Synonyms	4-(5-(Trifluoromethyl)-3,4,5,6-tetrahydro-2H-[1,2'-bipyridin]-4-yl)carboxylic acid; 4-(5-(Trifluoromethyl)-1,2,3,6-tetrahydropyridin-2-yl)nicotinic acid; 5'-Trifluoromethyl-1,2,3,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid; 4-Carboxy-5'-(trifluoromethyl)-3,4,5,6-tetrahydro-2H-1,2'-bipyridine; CAS 406476-31-1
EINECS	Contact for details

Quality Control

Our 5'-Trifluoromethyl-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade starting materials and compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.