Description

(S)-Azetidine-2-Carboxylic Acid HCl is a high-purity, non-proteinogenic amino acid derivative of significant importance in pharmaceutical research and development. This chiral building block is essential for the synthesis of novel bioactive molecules, particularly in the creation of peptidomimetics and constrained peptide analogs. It is a critical raw material for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries, enabling the exploration of new therapeutic modalities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the development of novel biochemical probes.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective organic synthesis.
• Agrochemical Research: Potential application in the development of novel, biologically active compounds for crop protection.
• Academic & Contract Research: Fundamental building block in university and CRO laboratories for exploratory medicinal chemistry projects.

Basic Information

Product Name	(S)-Azetidine-2-Carboxylic Acid HCl
CAS No.	405226-56-4
Molecular Formula	C4H8NO2·HCl
Molecular Weight	153.57 g/mol
Synonyms	(S)-2-Carboxyazetidine Hydrochloride; (S)-Azetidine-2-carboxylic acid hydrochloride; L-Azetidine-2-carboxylic acid hydrochloride; (S)-Aze-OH·HCl; Azetidine-2-carboxylic acid, (S)-, hydrochloride; (2S)-Azetidine-2-carboxylic acid hydrochloride; 405226-56-4
EINECS	Contact for details

Quality Control

Our (S)-Azetidine-2-Carboxylic Acid HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.