Description

4-Quinolinecarbonitrile, 6-Methyl-2-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block characterized by its quinoline core and strategically positioned nitrile and trifluoromethyl groups. This compound matters for its critical role in facilitating the synthesis of complex molecules, particularly in advanced pharmaceutical research and agrochemical development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce these functional motifs into novel active compounds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Material Science Research: Acts as a building block for creating advanced organic electronic materials, ligands for catalysis, and specialty polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Ligand and Catalyst Development: The quinoline and nitrile functionalities make it a useful scaffold for constructing novel ligands in transition metal catalysis.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research projects and scale-up campaigns.

Basic Information

Product Name	4-Quinolinecarbonitrile, 6-Methyl-2-(Trifluoromethyl)-
CAS No.	403665-34-9
Molecular Formula	C12H7F3N2
Molecular Weight	236.20 g/mol
Synonyms	6-Methyl-2-(trifluoromethyl)quinoline-4-carbonitrile; 2-(Trifluoromethyl)-6-methyl-4-quinolinecarbonitrile; 4-Cyano-6-methyl-2-(trifluoromethyl)quinoline; 6-Methyl-2-trifluoromethylquinoline-4-carbonitrile; Quinoline-4-carbonitrile, 6-methyl-2-(trifluoromethyl)-; 403665-34-9; 6-Methyl-2-(trifluoromethyl)-4-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Quinolinecarbonitrile, 6-Methyl-2-(Trifluoromethyl)- is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.