Description

Boc-(S)-3-Amino-4-(2-Bromo-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a brominated aromatic side chain. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other bioactive molecules. It is essential for research and development in medicinal chemistry, process chemistry, and peptide synthesis, where precise stereochemistry and functional group compatibility are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptide Mimetics & Conformationally Restricted Peptides: Used to incorporate non-natural, sterically constrained amino acid residues into peptide backbones to enhance stability and biological activity.
• Chemical Biology & Proteomics Research: Serves as a building block for designing activity-based probes, enzyme substrates, and molecular tools to study biological pathways.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale manufacturing of target drug candidates requiring this specific bromo-phenyl butyric acid scaffold.
• Custom Synthesis & Contract Manufacturing: A starting material for the bespoke synthesis of advanced intermediates for clients in the pharmaceutical and biotechnology sectors.

Basic Information

Product Name	Boc-(S)-3-Amino-4-(2-Bromo-Phenyl)-Butyric Acid
CAS No.	403661-78-9
Molecular Formula	C₁₅H₂₀BrNO₄
Molecular Weight	358.23 g/mol
Synonyms	(S)-3-[(tert-Butoxycarbonyl)amino]-4-(2-bromophenyl)butanoic acid; Boc-3-Amino-4-(2-bromophenyl)butyric acid; (3S)-3-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-(2-bromophenyl)butanoic acid; N-Boc-3-Amino-4-(2-bromo-phenyl)butyric acid; (S)-N-Boc-3-Amino-4-(2-bromophenyl)butyric acid; 2-Bromo-β-homophenylalanine N-Boc derivative; Boc-(S)-Amino(2-bromobenzyl)propionic acid
EINECS	Contact for details

Quality Control

Our Boc-(S)-3-Amino-4-(2-Bromo-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with high-grade pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.