Description

1-[8-Chloro-2-(Trifluoromethyl)Quinol-4-Yl]Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline-piperazine hybrid structure. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing novel bioactive molecules targeting various therapeutic areas. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers engaged in developing new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its quinoline and piperazine pharmacophores.
• Agrochemical Development: Employed in the research of novel pesticides and herbicides, leveraging its halogenated heterocyclic structure.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme inhibition and receptor binding.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for client projects.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-[8-Chloro-2-(Trifluoromethyl)Quinol-4-Yl]Piperazine
CAS No.	401567-90-6
Molecular Formula	C14H13ClF3N3
Molecular Weight	315.72 g/mol
Synonyms	8-Chloro-4-(piperazin-1-yl)-2-(trifluoromethyl)quinoline; 4-(Piperazin-1-yl)-8-chloro-2-(trifluoromethyl)quinoline; 1-(8-Chloro-2-(trifluoromethyl)-4-quinolyl)piperazine; 401567-90-6; 8-Chloro-2-trifluoromethyl-4-(1-piperazinyl)quinoline; 8-Chloro-2-(trifluoromethyl)-4-(piperazin-1-yl)quinoline
EINECS	Contact for details

Quality Control

Our 1-[8-Chloro-2-(Trifluoromethyl)Quinol-4-Yl]Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.