Description

4-Chloro-8-Fluoro-2-(Trifluoromethyl)Quinoline is a high-value, multi-functional heterocyclic building block distinguished by its unique halogen and trifluoromethyl substitution pattern. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structure imparts desirable electronic and steric properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine and chlorine atoms enhance bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport layers.
• Ligand and Catalyst Development: The quinoline core can be functionalized to create novel ligands for metal catalysis in fine chemical synthesis.
• Fluorinated Compound Library: An essential building block for combinatorial chemistry and the generation of diverse fluorinated compound libraries for high-throughput screening.
• Chemical Biology Probes: Used to develop molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	4-Chloro-8-Fluoro-2-(Trifluoromethyl)Quinoline
CAS No.	401567-85-9
Molecular Formula	C10H4ClF4N
Molecular Weight	249.59 g/mol
Synonyms	4-Chloro-8-fluoro-2-(trifluoromethyl)quinoline; 8-Fluoro-4-chloro-2-trifluoromethylquinoline; Quinoline, 4-chloro-8-fluoro-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-4-chloro-8-fluoroquinoline; 4-Chloro-8-fluoro-2-trifluoromethylquinoline; 401567-85-9; 4-Chloro-8-fluoro-2-(trifluoromethyl)quinoline (CAS 401567-85-9)
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Fluoro-2-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.