Description

2,8-Bis(Trifluoromethyl)-4-(Piperazin-1-Yl)Quinoline is a high-value, fluorinated quinoline derivative with a piperazine substituent, offering a unique combination of structural features for advanced chemical synthesis. This compound is critical for research and development in pharmaceutical and agrochemical discovery, where its trifluoromethyl groups and nitrogen heterocycles are prized for modulating biological activity and physicochemical properties. It serves as a sophisticated building block for medicinal chemists and process development scientists targeting novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in oncology, CNS, and anti-infective research.
• Agrochemical Research: Used in developing advanced pesticides and herbicides, leveraging the stability and lipophilicity imparted by the trifluoromethyl groups.
• Material Science: Investigated as a monomer or additive for specialty polymers and coatings requiring specific electronic or surface properties.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study enzyme function or protein-protein interactions.
• Organic Light-Emitting Diode (OLED) Research: Potential use in electron-transport or host materials due to its electron-deficient quinoline core.
• Catalyst Ligand Development: The piperazine nitrogen atoms can be functionalized to create novel ligands for transition metal catalysis.

Basic Information

Product Name	2,8-Bis(Trifluoromethyl)-4-(Piperazin-1-Yl)Quinoline
CAS No.	401567-76-8
Molecular Formula	C16H12F6N3
Molecular Weight	360.28 g/mol
Synonyms	4-(Piperazin-1-yl)-2,8-bis(trifluoromethyl)quinoline; 2,8-Bis(trifluoromethyl)-4-piperazinylquinoline; Quinoline, 2,8-bis(trifluoromethyl)-4-(1-piperazinyl)-; 401567-76-8; 4-(1-Piperazinyl)-2,8-bis(trifluoromethyl)quinoline
EINECS	Contact for details

Quality Control

Our 2,8-Bis(Trifluoromethyl)-4-(Piperazin-1-Yl)Quinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.