Description

1-[2,6-Bis(Trifluoromethyl)Quinol-4-Yl]Piperazine is a specialized heterocyclic compound featuring a quinoline core substituted with trifluoromethyl groups and a piperazine moiety. This structure is engineered to provide unique electronic and steric properties, making it a high-value intermediate for advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly in areas requiring fluorinated scaffolds for enhanced bioavailability and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for targets in oncology, CNS disorders, and infectious diseases.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides where the fluorinated quinoline structure can improve activity and environmental profile.
• Material Science Precursor: Serves as a monomer or functional additive in the development of advanced polymers, coatings, and electronic materials requiring specific fluorinated characteristics.
• Ligand Synthesis for Catalysis: Employed in the creation of novel ligands for metal-catalyzed reactions in fine chemical and asymmetric synthesis.
• Life Science Reagents: Utilized in the design and production of fluorescent probes, biochemical tools, and diagnostic agents.

Basic Information

Product Name	1-[2,6-Bis(Trifluoromethyl)Quinol-4-Yl]Piperazine
CAS No.	401567-74-6
Molecular Formula	C₁₅H₁₃F₆N₃
Molecular Weight	365.28 g/mol
Synonyms	4-(Piperazin-1-yl)-2,6-bis(trifluoromethyl)quinoline; 2,6-Bis(trifluoromethyl)-4-(1-piperazinyl)quinoline; 1-(2,6-Bis(trifluoromethyl)-4-quinolyl)piperazine; 401567-74-6; Quinoline, 4-(1-piperazinyl)-2,6-bis(trifluoromethyl)-; 4-Piperazinyl-2,6-bis(trifluoromethyl)quinoline
EINECS	Contact for details

Quality Control

Our 1-[2,6-Bis(Trifluoromethyl)Quinol-4-Yl]Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.