Description

3-(n-Fmoc-Amino)Pyrrolidine Hydrochloride is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of the 3-aminopyrrolidine moiety into complex peptide chains, enabling advanced pharmaceutical research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential assembly of peptides containing the 3-aminopyrrolidine structure.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based drugs, including GPCR-targeted therapies and enzyme inhibitors.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse libraries of compounds for high-throughput screening.
• Bioconjugation: Employed in the site-specific modification of peptides and proteins for creating targeted biopharmaceuticals or diagnostic probes.
• Academic Research: Fundamental research tool in biochemistry and medicinal chemistry for studying peptide structure-activity relationships (SAR).
• Custom Peptide Synthesis Services: A standard reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Item	Detail
Product Name	3-(n-Fmoc-Amino)Pyrrolidine Hydrochloride
CAS No.	400653-43-2
Molecular Formula	C20H22N2O2 • HCl
Molecular Weight	358.86 g/mol (Free base: 322.40 g/mol)
Synonyms	Fmoc-3-Aminopyrrolidine Hydrochloride; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-aminopyrrolidine Hydrochloride; 3-(Fmoc-amino)pyrrolidine HCl; N-α-Fmoc-3-aminopyrrolidine Hydrochloride; 3-[(9-Fluorenylmethyloxycarbonyl)amino]pyrrolidine Hydrochloride; (R/S)-3-(Fmoc-Amino)pyrrolidine Hydrochloride; Pyrrolidine-3-carboxylic acid, 3-amino-, N-Fmoc derivative, hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(n-Fmoc-Amino)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.