Description

1-Boc-Benzimidazole-5-Carboxylic Acid is a high-purity, protected heterocyclic carboxylic acid derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel drug candidates, especially in therapeutic areas targeting kinases and other key biological pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitor drugs.
• Peptidomimetic Research: Used to incorporate benzimidazole motifs into peptide backbones to enhance metabolic stability and binding affinity.
• Combinatorial Chemistry: A valuable scaffold for generating diverse compound libraries in high-throughput screening for drug discovery.
• Agrochemical Synthesis: Intermediate in the development of novel fungicides and herbicides that leverage the benzimidazole core.
• Material Science: Building block for specialty polymers and ligands used in catalysis and metal-organic frameworks (MOFs).
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for selective deprotection, enabling multi-step synthetic sequences.

Basic Information

Product Name	1-Boc-Benzimidazole-5-Carboxylic Acid
CAS No.	400653-36-3
Molecular Formula	C₁₃H₁₄N₂O₄
Molecular Weight	262.26 g/mol
Synonyms	1-[(tert-Butoxy)carbonyl]-1H-benzimidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; 1-Boc-5-carboxybenzimidazole; 5-Carboxy-1-Boc-benzimidazole; tert-Butyl 5-carboxy-1H-benzimidazole-1-carboxylate; 1-N-Boc-benzimidazole-5-carboxylic acid; Benzimidazole-5-carboxylic acid, N-Boc protected; BOC-Benzimidazole-5-COOH
EINECS	Contact for details

Quality Control

Every batch of 1-Boc-Benzimidazole-5-Carboxylic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are aligned with industry best practices for advanced pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment supports regulatory filings in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be stored away from direct light. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.