Description

Sulfoxonium, Dimethyl-, (3S)-3-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Oxo-4-Phenylbutylide is a sophisticated sulfoxonium ylide building block of significant interest in advanced organic synthesis. Its value lies in its role as a versatile reagent for the synthesis of complex, nitrogen-containing heterocycles and chiral intermediates, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting protease inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of protease inhibitor candidates and other novel therapeutic agents.
• Advanced Organic Synthesis: Utilized in cyclization and annulation reactions to construct complex nitrogen heterocycles, such as lactams and fused ring systems.
• Asymmetric Synthesis: Serves as a precursor for generating chiral centers in target molecules through controlled ylide reactions.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies during drug discovery.
• Process Chemistry Development: Used for scaling up synthetic routes to key intermediates under Good Manufacturing Practice (GMP) conditions.
• Academic & Industrial R&D: A valuable reagent for methodology development in synthetic organic chemistry laboratories.

Basic Information

Product Name	Sulfoxonium, Dimethyl-, (3S)-3-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Oxo-4-Phenylbutylide
CAS No.	400611-25-8
Molecular Formula	C17H25NO4S
Molecular Weight	339.45 g/mol
Synonyms	(3S)-3-[(tert-Butoxycarbonyl)amino]-2-oxo-4-phenylbutylidene(dimethyl)-λ6-sulfanone; tert-Butyl N-[(3S)-1-(dimethyl-λ6-sulfanylidene)-3-oxo-1-phenylbutan-2-yl]carbamate; (S)-tert-Butyl (1-(dimethyl(oxo)-λ6-sulfanylidene)-3-oxo-1-phenylbutan-2-yl)carbamate; Dimethylsulfoxonium (S)-3-((tert-butoxycarbonyl)amino)-2-oxo-4-phenylbutylide; Boc-L-Phe-sulfoxonium ylide; Sulfoxonium ylide of Boc-Phenylalanine
EINECS	Contact for details

Quality Control

Our Sulfoxonium, Dimethyl-, (3S)-3-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Oxo-4-Phenylbutylide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.