Description

(R)-(-)-Phenylsuccinic Acid CAS NO 46292-93-7 is a high-purity chiral building block and resolving agent of significant importance in asymmetric synthesis. Its single enantiomer purity makes it a critical intermediate for the development of active pharmaceutical ingredients (APIs) and fine chemicals with specific stereochemical requirements. This compound is essential for research and production in the pharmaceutical, agrochemical, and advanced materials sectors where precise molecular handedness dictates biological activity and material properties.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key building block for the production of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutics.
• Resolution Agent: Used for the chiral separation of racemic mixtures of amines, amino acids, and other pharmaceutically relevant compounds via diastereomeric salt formation.
• Ligand Precursor for Asymmetric Catalysis: Serves as a starting material for synthesizing chiral ligands used in metal-catalyzed asymmetric reactions, such as hydrogenations and hydroxylations.
• Agrochemical Intermediate: Employed in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Advanced Material Synthesis: A monomer or precursor for chiral polymers and liquid crystals with specialized optical properties.
• Academic & Industrial R&D: A standard reagent in research laboratories for method development in stereochemistry and process chemistry.

Basic Information

Item	Detail
Product Name	(R)-(-)-Phenylsuccinic Acid
CAS No.	46292-93-7
Molecular Formula	C10H10O4
Molecular Weight	194.18 g/mol
Synonyms	(R)-2-Phenylsuccinic Acid; (R)-(-)-2-Phenylbutanedioic Acid; D-(-)-Phenylsuccinic Acid; (2R)-2-Phenylbutanedioic Acid; (R)-α-Phenylsuccinic Acid; (R)-1,2-Benzenediacetic Acid; Phenylsuccinic Acid (R)-enantiomer
EINECS	Contact for details

Quality Control

Our (R)-(-)-Phenylsuccinic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet the highest standards. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for chiral purity (HPLC), chemical purity (HPLC), specific rotation, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Specific Rotation [α]20/D	-70° to -76° (c=1 in Methanol)
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.