Description

2-Chloromethyloxetane is a versatile and highly reactive oxetane derivative, serving as a crucial building block in advanced organic synthesis. Its value lies in the presence of both a strained oxetane ring and a reactive chloromethyl group, enabling efficient ring-opening and functionalization reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and polymer industries, where it is used to introduce the oxetane moiety to enhance the physicochemical properties of target molecules.

Application

• Pharmaceutical Intermediates: Key synthon for introducing the metabolically stable oxetane bioisostere into drug candidates to improve metabolic stability, solubility, and potency.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides, where the oxetane ring can influence biological activity and environmental fate.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for synthesizing specialty polymers, coatings, and resins with tailored thermal and mechanical properties.
• Ligand & Catalyst Development: Employed in the synthesis of complex ligands and organocatalysts for asymmetric synthesis and metal-organic frameworks (MOFs).
• Surface Modification: Utilized to functionalize surfaces and nanoparticles via the reactive chloromethyl group, enabling the attachment of various biomolecules or polymers.

Basic Information

Product Name	2-Chloromethyloxetane
CAS No.	45377-87-5
Molecular Formula	C4H7ClO
Molecular Weight	106.55 g/mol
Synonyms	2-(Chloromethyl)oxetane; Oxetane, 2-(chloromethyl)-; 3-Oxetanemethanol, 2-chloro-; 2-Chlorooxetane-2-methanol; (Chloromethyl)oxetane; 2-Oxetanylmethyl chloride
EINECS	Contact for details

Quality Control

Our 2-Chloromethyloxetane is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as oxidizing agents. Due to its reactivity, it is recommended to store under an inert atmosphere for long-term stability and to use promptly after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.