Description

(S)-2-Amino-2-Methyl-Butyric Acid Hydrochloride is a high-purity, non-proteinogenic amino acid derivative in its hydrochloride salt form, offering enhanced stability and solubility for advanced synthesis. This chiral building block is critical for pharmaceutical research and development, particularly in the creation of peptidomimetics and active pharmaceutical ingredients (APIs). It is essential for chemists and formulators in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for complex organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially peptidomimetics and enzyme inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce sterically hindered, non-natural amino acid residues.
• Biochemical Research: Serves as a precursor or standard in metabolic pathway studies and proteomics research.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective catalytic reactions.
• Agrochemical Development: Potential intermediate in the synthesis of advanced, chiral crop protection agents.
• Diagnostic Reagents: Can be utilized in the development of specialized reagents and biomarkers.

Basic Information

Product Name	(S)-2-Amino-2-Methyl-Butyric Acid Hydrochloride
CAS No.	43177-22-6
Molecular Formula	C5H12ClNO2
Molecular Weight	153.61 g/mol
Synonyms	(S)-2-Amino-2-methylbutyric acid hydrochloride; (S)-2-Methyl-2-aminobutyric acid hydrochloride; L-2-Amino-2-methylbutyric acid hydrochloride; (S)-2-Amino-2-methylbutanoic acid hydrochloride; (S)-α-Aminoisovaleric acid hydrochloride (ambiguous); (S)-2-Methyl-2-aminobutanoic acid hydrochloride; H-Aib(2-Me)-OH.HCl; (S)-2-Amino-2-methylbutyrate hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-2-Methyl-Butyric Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Chloride Content (Titration)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.