Description

(3R,4S)-3-[(4R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-4-Methoxy-7,7-Dimethyl-2,6,8-Trioxabicyclo[3.3.0]Octane is a high-purity, chiral bicyclic acetal compound of significant interest in advanced organic synthesis. Its complex, rigid structure makes it a valuable key chiral building block and protecting group precursor for the development of pharmaceuticals and fine chemicals. This product is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require sophisticated intermediates with defined stereochemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of complex drug molecules, particularly those targeting central nervous system and antiviral applications.
• Asymmetric Synthesis: Used as a chiral auxiliary or scaffold to induce stereoselectivity in catalytic and stoichiometric organic reactions.
• Advanced Protecting Group Chemistry: The acetal functionality acts as a protecting group for diols or carbonyls under specific conditions, enabling multi-step synthetic sequences.
• Agrochemical Research: Employed in the development of novel, enantiomerically pure active ingredients for crop protection.
• Material Science Precursor: Potential use in the synthesis of chiral ligands for catalysis or monomers for specialized polymers.
• Academic & R&D: A valuable compound for methodological studies in organic chemistry and the development of new synthetic pathways.

Basic Information

Product Name	(3R,4S)-3-[(4R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-4-Methoxy-7,7-Dimethyl-2,6,8-Trioxabicyclo[3.3.0]Octane
CAS No.	43138-64-3
Molecular Formula	C13H22O6
Molecular Weight	274.31 g/mol
Synonyms	(3R,4S)-3-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-4-methoxy-7,7-dimethyl-2,6,8-trioxabicyclo[3.3.0]octane; 1,2:5,6-Di-O-isopropylidene-3-O-methyl-α-D-glucofuranose; 3-O-Methyl-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose; 3-O-Methyl-diisopropylidene glucose; Methyl ether of diacetone glucose; 3-O-Methyl-1,2:5,6-di-O-(1-methylethylidene)-α-D-glucofuranose; 3-Methoxy-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose
EINECS	Contact for details

Quality Control

Our production of (3R,4S)-3-[(4R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-4-Methoxy-7,7-Dimethyl-2,6,8-Trioxabicyclo[3.3.0]Octane adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, Chiral HPLC, and NMR to verify specifications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.