Description

n-Nitrosodiphenylamine-D10 is a deuterated internal standard specifically designed for high-precision analytical applications. This compound is essential for ensuring accurate quantification and method validation in mass spectrometry, particularly for the analysis of its non-deuterated counterpart and related nitrosamine impurities. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental monitoring sectors who require the highest level of data integrity and regulatory compliance.

Application

• Primary use as an internal standard for the quantitative analysis of n-Nitrosodiphenylamine via LC-MS/MS and GC-MS.
• Method development and validation for nitrosamine impurity testing in active pharmaceutical ingredients (APIs) and finished drug products.
• Research applications in studying the environmental fate, metabolism, and toxicokinetics of nitrosamine compounds.
• Quality control and assurance in chemical manufacturing to monitor for nitrosamine formation.
• Calibration standard for analytical instrumentation in compliance with ICH Q3A/B, Q2(R1), and other regulatory guidelines.
• Use in stable isotope dilution assays to achieve superior accuracy and precision in trace-level analysis.

Basic Information

Product Name	n-Nitrosodiphenylamine-D10
CAS No.	42952-91-0
Molecular Formula	C12D10N2O
Molecular Weight	204.27 g/mol
Synonyms	N-Nitroso-N-phenylbenzenamine-D10; Diphenylnitrosamine-D10; N-Nitrosodiphenylamine-d10; NDPhA-D10; N-Nitroso-N-phenylaniline-D10; N-Nitrosodiphenylamine (phenyl-d5,ring-d5); NDPA-D10; Deuterated N-Nitrosodiphenylamine
EINECS	Contact for details

Quality Control

Our n-Nitrosodiphenylamine-D10 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic purity, and related substance analysis. We adhere to relevant industry best practices to support our customers' needs for GMP and GLP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated place. For long-term storage, consider freezing at -20°C.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration Degree)	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.