Description

n-Me-Leu-Obzl p-Tosylate is a protected amino acid derivative, specifically the p-tosylate salt of N-methyl-L-leucine benzyl ester. This compound is a crucial building block in advanced organic synthesis, particularly in the production of complex peptides and peptidomimetics where the introduction of a hydrophobic, N-methylated leucine residue is required. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry and the synthesis of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for incorporating N-methyl-leucine into peptide chains to enhance metabolic stability and membrane permeability.
• Medicinal Chemistry Research: For the design and synthesis of peptide-based drug candidates, protease inhibitors, and other bioactive molecules.
• Pharmaceutical Intermediate: In the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Chemical Biology Studies: Used to create modified peptides for probing protein-protein interactions and enzyme mechanisms.
• Process Development: Serves as a standardized, high-purity starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	n-Me-Leu-Obzl p-Tosylate
CAS No.	42807-66-9
Molecular Formula	C22H29NO5S
Molecular Weight	419.54 g/mol
Synonyms	N-Methyl-L-leucine benzyl ester p-toluenesulfonate salt; Benzyl N-methyl-L-leucinate 4-methylbenzenesulfonate; (S)-Benzyl 2-((methylamino)methyl)-4-methylpentanoate p-toluenesulfonate; N-Me-Leu-OBzl Tosylate; N-Methylleucine benzyl ester tosylate; Leu(Me)-OBzl.TosOH; Bzl-N-Me-Leu-OTs
EINECS	Contact for details

Quality Control

Our n-Me-Leu-Obzl p-Tosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.