Description

Mercaptodextran CAS NO 42612-66-8 is a functionalized polysaccharide derivative where thiol (-SH) groups are introduced onto a dextran backbone, creating a versatile platform for bioconjugation and material science. This modification is critical as it provides reactive sites for forming stable thioether bonds with maleimides or disulfide linkages, enabling precise and robust attachment of biomolecules, drugs, or nanoparticles. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biomedical, and diagnostic sectors who require a water-soluble, biocompatible polymer for drug delivery systems, hydrogel formation, surface modification, and protein or peptide immobilization.

Application

• Drug Delivery Systems: As a carrier for controlled and targeted release of therapeutic agents, leveraging its ability to form disulfide-crosslinked nanoparticles or micelles that are responsive to reducing environments.
• Hydrogel Fabrication: Serving as a crosslinkable component for creating biocompatible and biodegradable hydrogels used in tissue engineering scaffolds and wound dressings.
• Protein & Antibody Conjugation: Facilitating the site-specific attachment of proteins, antibodies, or enzymes for the development of diagnostics, biosensors, and affinity chromatography media.
• Surface Functionalization: Modifying the surface of gold nanoparticles, quantum dots, or other materials to improve biocompatibility, stability, and provide functional handles for further coupling.
• Biomaterial Coating: Creating non-fouling or bioactive coatings on medical devices and implants to enhance biocompatibility and reduce immune response.
• Cell Culture & Tissue Engineering: As a component of extracellular matrix (ECM)-mimicking materials to promote cell adhesion, proliferation, and differentiation.

Basic Information

Product Name	Mercaptodextran
CAS No.	42612-66-8
Molecular Formula	(C6H10O5)n with -SH modifications
Molecular Weight	Variable (based on dextran backbone and degree of substitution)
Synonyms	Thiolated Dextran; Dextran-SH; Dextran Mercaptan; SH-Dextran; Dextran Thiol; Thiodextran; Dextran derivative with thiol groups; Poly(dextran-co-thiol)
EINECS	Contact for details

Quality Control

Our Mercaptodextran is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure consistency and performance. Key parameters such as degree of thiol substitution, molecular weight distribution, purity, and endotoxin levels are controlled. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation of the thiol groups and prevent moisture absorption. For long-term stability, desiccants are recommended. Allow the product to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (IR)	Conforms to structure
Degree of Thiol Substitution	Customizable (e.g., 10 - 200 µmol/g)
Molecular Weight (Dextran Backbone)	Customizable (e.g., 10 kDa, 40 kDa, 70 kDa)
Purity (HPLC)	≥ 95%
Solubility	Freely soluble in water and aqueous buffers
Endotoxin	< 0.1 EU/mg (for research/grade-specific)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.