Description

Thp-Peg10-Oh CAS NO 42607-90-9 is a specialized polyethylene glycol derivative featuring a tetrahydropyranyl (THP) protecting group. This bifunctional molecule is critical for controlled synthesis in advanced organic and polymer chemistry, offering a reactive hydroxyl terminus for further conjugation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and specialty polymer industries for developing drug delivery systems, functionalized materials, and complex molecular architectures.

Application

• Pharmaceutical Intermediates: Serves as a key building block and linker in the synthesis of prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutics.
• Bioconjugation Chemistry: Used to introduce hydrophilic PEG spacers or as a protected intermediate for attaching drugs, dyes, or targeting ligands to biomolecules like proteins and peptides.
• Polymer Functionalization: Acts as a monofunctional initiator or terminating agent in the synthesis of block copolymers and functionalized PEG derivatives with controlled architecture.
• Material Science: Employed in the surface modification of nanoparticles and biomaterials to enhance biocompatibility, solubility, and stealth properties.
• Cross-linking Agent: Utilized in the preparation of hydrogels and polymer networks where a degradable or cleavable linker is required.
• Research & Development: A valuable tool compound in organic synthesis labs for multi-step reactions requiring orthogonal protection/deprotection strategies.

Basic Information

Product Name	Thp-Peg10-Oh
CAS No.	42607-90-9
Molecular Formula	C25H50O12
Molecular Weight	542.66 g/mol
Synonyms	2-(2-(2-(2-(2-(2-(2-(2-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol; THP-PEG10-OH; Tetrahydropyranyl-PEG10-alcohol; α-THP-ω-hydroxy-decaethylene glycol; 3,6,9,12,15,18,21,24,27,30-Decaoxadotetracontan-32-ol, 2-(tetrahydro-2H-pyran-2-yloxy)-; THP-protected PEG10 alcohol; PEG10 mono-THP ether
EINECS	Contact for details

Quality Control

Our Thp-Peg10-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC)	500 - 580 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.