Description

2-[(2E)-4-Bromobut-2-En-1-Yl]-1H-Isoindole-1,3(2H)-Dione is a specialized brominated phthalimide derivative, serving as a crucial high-purity synthetic intermediate for advanced organic synthesis. Its unique structure, featuring both an activated alkene and a phthalimide-protected amine precursor, makes it an invaluable building block for constructing complex molecules. This compound is primarily sought by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring functionalized amine or alkene components.
• Peptide Mimetics & PROTACs: Used in the construction of peptide-like structures and Proteolysis Targeting Chimeras (PROTACs) due to its versatile reactivity.
• Ligand & Catalyst Synthesis: Serves as a building block for creating novel ligands and organocatalysts in asymmetric synthesis.
• Polymer & Material Science: Intermediate for synthesizing functional monomers and specialty polymers with tailored properties.
• Agrochemical Research: Used in the development of novel crop protection agents and herbicides.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and protein function.

Basic Information

Product Name	2-[(2E)-4-Bromobut-2-En-1-Yl]-1H-Isoindole-1,3(2H)-Dione
CAS No.	42561-71-7
Molecular Formula	C₁₂H₁₀BrNO₂
Molecular Weight	280.12 g/mol
Synonyms	N-(4-Bromo-2-butenyl)phthalimide; (E)-N-(4-Bromobut-2-en-1-yl)phthalimide; 4-Bromo-2-butenylphthalimide; 1-(4-Bromo-2-butenyl)phthalimide; 2-(4-Bromo-2-butenyl)isoindoline-1,3-dione; Phthalimide, N-(4-bromo-2-butenyl)-; (E)-N-(4-Bromobut-2-enyl)phthalimide
EINECS	Contact for details

Quality Control

Our 2-[(2E)-4-Bromobut-2-En-1-Yl]-1H-Isoindole-1,3(2H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.