Description

Boc-Gly-Ocs Salt is a protected amino acid derivative widely used as a key building block in peptide synthesis. Its primary value lies in providing a tert-butoxycarbonyl (Boc) protected glycine residue, which is crucial for the controlled elongation of peptide chains in solid-phase and solution-phase methodologies. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel therapeutic peptides and biochemical probes. The compound, identified by CAS No. 42538-64-7, is known for its specific reactivity profile and requires careful handling due to its moisture-sensitive nature.

Application

• Pharmaceutical Intermediates: Critical building block for the synthesis of complex therapeutic peptides and peptidomimetics.
• Solid-Phase Peptide Synthesis (SPPS): Used in Fmoc/t-Boc strategies for the sequential addition of glycine residues with orthogonal protection.
• Bioconjugation: Serves as a reagent for introducing glycine linkers or spacers in antibody-drug conjugates (ADCs) and protein labeling.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening.
• Biochemical Research: Utilized in academic and industrial R&D for studying peptide structure, function, and interactions.
• Custom Peptide Production: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Boc-Gly-Ocs Salt
CAS No.	42538-64-7
Molecular Formula	C8H15NO5S
Molecular Weight	237.27 g/mol
Synonyms	N-(tert-Butoxycarbonyl)glycine O-succinimidyl ester salt; Boc-Glycine N-hydroxysuccinimide ester salt; Boc-Gly-OSu salt; N-Boc-glycine succinimidyl ester salt; (2,5-Dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester; Boc-Gly-ONSu salt; N-α-Boc-glycine N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Boc-Gly-Ocs Salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, chiral purity, and residual solvent levels to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.