Description

Boc-His-Nhnh2 is a protected histidine derivative, specifically the Boc-hydrazide of histidine, widely used as a key synthetic intermediate in peptide chemistry. Its primary value lies in enabling the controlled synthesis and modification of peptides, particularly those containing the histidine residue, which is crucial for catalytic and metal-binding functions. This high-purity building block is essential for researchers and manufacturers in pharmaceutical development, proteomics research, and the production of specialized bioactive peptides.

Application

• Peptide Synthesis: A critical building block for the solid-phase and solution-phase synthesis of complex peptides, especially those requiring selective deprotection strategies.
• Pharmaceutical Intermediates: Serves as a key precursor in the research and development of novel therapeutic peptides and peptidomimetics targeting various diseases.
• Bioconjugation & Labeling: Utilized for site-specific conjugation of probes, tags, or drug molecules to peptides and proteins via its reactive hydrazide group.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and inhibitors for studying enzyme mechanisms, particularly those involving histidine.
• Catalytic Peptide Research: Used to construct artificial enzymes and catalytic peptides where the imidazole side chain of histidine plays a vital role.
• Material Science: Acts as a functional monomer for creating novel bio-inspired polymers and smart materials with specific molecular recognition properties.

Basic Information

Product Name	Boc-His-Nhnh2
CAS No.	42002-05-1
Molecular Formula	C11H19N5O4
Molecular Weight	285.30 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-histidine hydrazide; Boc-L-histidine hydrazide; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(1H-imidazol-5-yl)propanehydrazide; tert-Butoxycarbonylhistidine hydrazide; Boc-His-NHNH2; BOC-HIS-HYD; Boc-His-Hz
EINECS	Contact for details

Quality Control

Every batch of Boc-His-Nhnh2 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.