Description

2-[(S)-3-(1H-Imidazol-4-Yl)-1-Oxo-2-[[(Benzyloxy)Carbonyl]Amino]Propyl]Hydrazine-1-Carboxylic Acid tert-Butyl Ester is a sophisticated chiral building block and protected amino acid derivative of significant interest in advanced organic synthesis. This compound is engineered to provide a versatile and reactive scaffold for the construction of complex peptide mimetics and heterocyclic molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme modulators, and other bioactive peptide-based drug candidates.
• Peptidomimetic Research: Serves as a protected scaffold for constructing non-natural amino acid sequences and exploring structure-activity relationships (SAR) in medicinal chemistry.
• Chemical Biology Probes: Used in the development of labeled or tagged compounds for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis Building Block: Employed in contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex target molecules for clients.
• Academic Research: Utilized in university laboratories for methodological development in asymmetric synthesis and peptide coupling strategies.

Basic Information

Item	Detail
Product Name	2-[(S)-3-(1H-Imidazol-4-Yl)-1-Oxo-2-[[(Benzyloxy)Carbonyl]Amino]Propyl]Hydrazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	41445-68-5
Molecular Formula	C19H25N5O5
Molecular Weight	403.44 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-L-histidyl hydrazide, N-CBZ-L-histidyl hydrazide; CBZ-L-His-NHNH2; Z-L-His-NHNH2; (S)-2-((((Benzyloxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoyl)hydrazine; tert-Butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-(1H-imidazol-4-yl)propanehydrazidate; Boc-L-His(Cbz)-NHNH2
EINECS	Contact for details

Quality Control

Every batch of our 2-[(S)-3-(1H-Imidazol-4-Yl)-1-Oxo-2-[[(Benzyloxy)Carbonyl]Amino]Propyl]Hydrazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent decomposition. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.