Description

n-Acetyl-D-Glucosaminyl-(1-4)-n-Acetylmuramic Acid is a key disaccharide component of bacterial peptidoglycan, the essential structural polymer of the cell wall. This compound is of significant value for researchers studying bacterial cell wall biosynthesis, structure, and the mechanisms of action for antibiotics like β-lactams and glycopeptides. It serves as a critical biochemical tool and reference standard for pharmaceutical R&D, microbiology, and enzymology laboratories focused on developing novel antimicrobial agents and diagnostic assays.

Application

• Biochemical Research: As a substrate or inhibitor for enzymes involved in peptidoglycan synthesis and remodeling, such as transglycosylases and lytic transglycosylases.
• Antibiotic Mechanism Studies: Used to investigate the binding and inhibitory action of antibiotics (e.g., vancomycin, moenomycin) that target cell wall precursors.
• Reference Standard: Serves as a high-purity analytical standard for HPLC, LC-MS, or NMR to quantify peptidoglycan fragments in complex biological samples.
• Enzyme Assay Development: Essential for developing high-throughput screening assays to discover new antibacterial compounds targeting cell wall biosynthesis.
• Immunology Research: Can be used to study innate immune recognition, as peptidoglycan fragments are known pathogen-associated molecular patterns (PAMPs).
• Synthetic Biology: Acts as a building block for the chemoenzymatic synthesis of more complex peptidoglycan structures for structural and functional studies.

Basic Information

Product Name	n-Acetyl-D-Glucosaminyl-(1-4)-n-Acetylmuramic Acid
CAS No.	41137-10-4
Molecular Formula	C22H38N2O15
Molecular Weight	570.55 g/mol
Synonyms	N-Acetylglucosaminyl-N-acetylmuramic Acid; MurNAc-GlcNAc; Disaccharide Peptidoglycan Monomer; N-Acetylmuramic Acid-(1→4)-N-Acetylglucosamine; GlcNAc-MurNAc; PG Disaccharide; Peptidoglycan Disaccharide; AECM
EINECS	Contact for details

Quality Control

Our n-Acetyl-D-Glucosaminyl-(1-4)-n-Acetylmuramic Acid is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR structural confirmation, and mass spectrometry, to ensure identity, purity, and consistency for critical research applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.