Description

Potassium Bis(Trimethylsilyl)Amide (CAS NO 40949-94-8) is a highly reactive, non-nucleophilic strong base widely used in organic synthesis. Its primary value lies in its ability to deprotonate a broad range of weak acids under mild conditions, facilitating critical bond-forming reactions. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where precise control over reaction pathways is paramount.

Application

• As a strong, sterically hindered base for the deprotonation of sensitive substrates in pharmaceutical intermediate synthesis.
• Key reagent in metal-halogen exchange reactions for the generation of functionalized organometallic compounds.
• Catalyst and initiator for anionic polymerization processes, enabling the production of specialized polymers and elastomers.
• Used in the synthesis of silyl enol ethers and other protected intermediates for complex molecule construction.
• Employed in deprotonative functionalization of heterocyclic compounds in medicinal chemistry.
• Facilitates asymmetric synthesis when used in conjunction with chiral ligands or auxiliaries.
• Preparation of high-purity semiconductor precursors and other electronic chemicals.

Basic Information

Product Name	Potassium Bis(Trimethylsilyl)Amide
CAS No.	40949-94-8
Molecular Formula	C6H18KNSi2
Molecular Weight	199.48 g/mol
Synonyms	Potassium Hexamethyldisilazide; Potassium HMDS; KHMDS; Potassium Bis(trimethylsilyl)amide; 1,1,1-Trimethyl-N-(trimethylsilyl)silanaminato potassium; Potassium (Trimethylsilyl)amide; Potassium Bis(TMS)amide
EINECS	Contact for details

Quality Control

Our Potassium Bis(Trimethylsilyl)Amide is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We provide comprehensive analytical data, including assay by titration and impurity profile by NMR/GC. A Certificate of Analysis (COA) detailing purity, identity, and relevant specifications is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Solubility (Test)	Soluble in common organic solvents (e.g., THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.