Description

6-Chloro-2-Bromo-9-(2,3,5-Tri-o-Acetyl)-β-D-Ribofuranosyl-9H-Purine is a key nucleoside derivative and a critical advanced intermediate in the synthesis of modified purine analogues. This compound is valued for its role in introducing specific halogenated and protected functionalities into complex molecular scaffolds, enabling precise chemical modifications. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of antiviral agents, anticancer therapeutics, and other nucleotide-based bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel purine nucleoside analogues with potential antiviral or antitumor activity.
• Antiviral Drug Research: Used in the research and development of nucleotide reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Oncology Research: Serves as a precursor in creating purine-based molecules for targeted cancer therapies and apoptosis inducers.
• Biochemical Tool Compound: Employed in enzymatic studies and as a substrate or inhibitor for purine-metabolizing enzymes like kinases and phosphorylases.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., C-13, N-15) nucleosides for metabolic tracing and imaging studies.
• Oligonucleotide Synthesis: Used to incorporate modified bases into oligonucleotides for antisense, siRNA, or aptamer applications to enhance stability and binding affinity.

Basic Information

Item	Detail
Product Name	6-Chloro-2-Bromo-9-(2,3,5-Tri-o-Acetyl)-β-D-Ribofuranosyl-9H-Purine
CAS No.	40896-58-0
Molecular Formula	C16H16BrClN4O7
Molecular Weight	491.68 g/mol
Synonyms	2-Bromo-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine; 6-Chloro-2-bromopurine riboside triacetate; 9-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-6-chloro-2-bromo-9H-purine; 2-Bromo-6-chloropurine-9-ribofuranoside 2',3',5'-triacetate; 6-Chloro-2-bromoadenosine 2',3',5'-triacetate (common name); 40896-58-0; 6-Cl-2-Br-9-(triacetylribofuranosyl)purine
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Bromo-9-(2,3,5-Tri-o-Acetyl)-β-D-Ribofuranosyl-9H-Purine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.