Description

1-(Chloro-Difluoro-Methoxy)-4-Nitro-Benzene is a specialized halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro-difluoromethoxy and nitro substituents, makes it a valuable precursor for creating complex molecules with tailored electronic and physical properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the nitro and halogenated alkoxy groups contribute to biological activity.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialty polymers and liquid crystals with specific dielectric or optical properties.
• Organic Electronics: Employed in the development of novel electron-accepting materials for applications in organic light-emitting diodes (OLEDs) or semiconductors.
• Chemical Research: A versatile reagent for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl systems.
• Dye and Pigment Intermediate: Acts as a precursor in the synthesis of specialized azo dyes and pigments, leveraging its nitro group for chromophore development.

Basic Information

Product Name	1-(Chloro-Difluoro-Methoxy)-4-Nitro-Benzene
CAS No.	40750-71-8
Molecular Formula	C7H4ClF2NO3
Molecular Weight	223.56 g/mol
Synonyms	4-Nitro-1-(chlorodifluoromethoxy)benzene; p-Nitro(chlorodifluoromethoxy)benzene; Benzene, 1-(chlorodifluoromethoxy)-4-nitro-; 1-Chloro-2,2-difluoro-2-(4-nitrophenoxy)methane; 4-Nitrophenyl chlorodifluoromethyl ether; (Chlorodifluoromethoxy)-4-nitrobenzene
EINECS	Contact for details

Quality Control

Our 1-(Chloro-Difluoro-Methoxy)-4-Nitro-Benzene is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from techniques including HPLC, GC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.