Description

Hydroxylamine Hcl (15N) is a stable isotope-labeled derivative of hydroxylamine hydrochloride, where the nitrogen atom is enriched with the 15N isotope. This compound is essential for advanced research and analytical applications requiring isotopic tracing, providing critical insights into reaction mechanisms and metabolic pathways. It is primarily utilized by pharmaceutical researchers, agrochemical developers, and academic institutions engaged in sophisticated NMR spectroscopy and mass spectrometry studies. The product is supplied with a high isotopic and chemical purity to ensure reliable and reproducible experimental results.

Application

• Isotopic Tracer in Metabolic Studies: Used in pharmaceutical and biochemical research to track the incorporation of nitrogen in drug metabolites and biological molecules.
• NMR Spectroscopy Internal Standard: Serves as a crucial reference standard in Nuclear Magnetic Resonance (NMR) for quantitative analysis and structure elucidation.
• Mass Spectrometry Labeling Reagent: Employed in proteomics and metabolomics for stable isotope labeling to enable accurate quantification via LC-MS or GC-MS.
• Synthesis of Labeled Compounds: A key building block for synthesizing other 15N-labeled fine chemicals, intermediates, and active pharmaceutical ingredients (APIs).
• Environmental Fate Studies: Applied in agrochemical research to study the environmental degradation and transformation pathways of nitrogen-containing compounds.
• Catalysis and Mechanistic Research: Utilized in chemical research to investigate reaction mechanisms, particularly in reduction and oxime formation reactions.

Basic Information

Product Name	Hydroxylamine Hcl (15N)
CAS No.	40711-48-6
Molecular Formula	H4Cl15NO
Molecular Weight	70.49 g/mol (for 15N)
Synonyms	Hydroxylamine-15N hydrochloride; Hydroxylammonium-15N chloride; 15N-Labeled hydroxylamine HCl; HA-15N hydrochloride; Oxammonium-15N chloride; [15N]Hydroxylamine hydrochloride; Isotopic hydroxylamine HCl; Nitrogen-15 hydroxylamine hydrochloride
EINECS	Contact for details

Quality Control

Our Hydroxylamine Hcl (15N) is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity. Each batch is analyzed to confirm identity, assay, isotopic enrichment, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for isotopic purity (typically >98 atom % 15N), chemical purity (by HPLC/NMR), and related substances. We adhere to cGMP principles for research-grade materials, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air and moisture must be avoided. For long-term stability, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Isotopic Purity (15N)	≥ 98 atom %
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.