Description

4-Chloro-8-Trifluoromethoxyquinoline is a high-value, multi-functional heterocyclic building block and advanced pharmaceutical intermediate. Its unique molecular structure, featuring both chloro and trifluoromethoxy substituents on the quinoline core, makes it a critical precursor for synthesizing complex molecules with tailored biological and material properties. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory research pipelines.
• Agrochemical Synthesis: Serves as a core structure for creating new generation pesticides, herbicides, and fungicides with enhanced efficacy and environmental profile.
• Material Science Research: Used in the synthesis of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the design of chemical probes and inhibitors for target identification and validation studies.
• Catalyst & Ligand Development: Acts as a precursor for nitrogen-containing ligands used in transition metal catalysis for cross-coupling and other synthetic transformations.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP or ISO standards for client-specific molecules.

Basic Information

Product Name	4-Chloro-8-Trifluoromethoxyquinoline
CAS No.	40516-42-5
Molecular Formula	C11H5ClF3NO
Molecular Weight	259.61 g/mol
Synonyms	4-Chloro-8-(trifluoromethoxy)quinoline; 8-Trifluoromethoxy-4-chloroquinoline; Quinoline, 4-chloro-8-(trifluoromethoxy)-; 4-Chloro-8-trifluoromethoxy-quinoline; 4-Chloro-8-trifluoromethoxyquinoline; 4-Chloro-8-(trifluoromethoxy)quinoline; 40516-42-5 (CAS); 4-Cl-8-OCF3-Quinoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Trifluoromethoxyquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production can be aligned with cGMP and ISO 9001 standards for pharmaceutical and advanced industrial applications, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.