Description

4-Hydroxy-8-Trifluoromethoxyquinoline-3-Carboxylic Acid is a high-value, multifunctional quinoline derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular structure, featuring both a carboxylic acid and a trifluoromethoxy group, makes it indispensable for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in antimicrobial and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Serves as a precursor for functionalized organic materials and ligands for metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies.
• Fluorinated Compound Production: The trifluoromethoxy group provides a source for introducing fluorine, a key element in enhancing metabolic stability and lipophilicity in bioactive molecules.

Basic Information

Product Name	4-Hydroxy-8-Trifluoromethoxyquinoline-3-Carboxylic Acid
CAS No.	40516-40-3
Molecular Formula	C₁₁H₆F₃NO₄
Molecular Weight	273.17 g/mol
Synonyms	8-(Trifluoromethoxy)-4-hydroxyquinoline-3-carboxylic acid; 4-Hydroxy-8-(trifluoromethoxy)quinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 4-hydroxy-8-(trifluoromethoxy)-; 4-Hydroxy-8-trifluoromethoxy-quinoline-3-carboxylic acid; 4-Hydroxy-8-trifluoromethoxy-3-quinolinecarboxylic acid; 40516-40-3; 8-Trifluoromethoxy-4-hydroxyquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-8-Trifluoromethoxyquinoline-3-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.