Description

4-Hydroxy-8-Trifluoromethoxyquinoline-3-Carboxylic Acid Ethyl Ester is a high-value, multi-functional quinoline derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture, featuring both a trifluoromethoxy group and a carboxylic acid ester, makes it an essential building block for creating compounds with enhanced biological activity and physicochemical properties. This product is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in antimicrobial, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethoxy group can improve metabolic stability and lipophilicity.
• Material Science Research: Serves as a precursor for functionalized organic molecules used in electronic materials or as ligands in catalytic systems.
• Chemical Reference Standard: Employed in analytical laboratories for method development, validation, and quality control testing of related compounds.
• Academic & R&D: Utilized in university and corporate research for exploring novel organic reactions and synthesizing complex heterocyclic libraries.

Basic Information

Product Name	4-Hydroxy-8-Trifluoromethoxyquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	40516-39-0
Molecular Formula	C₁₃H₁₀F₃NO₄
Molecular Weight	301.22 g/mol
Synonyms	Ethyl 4-hydroxy-8-(trifluoromethoxy)quinoline-3-carboxylate; 8-Trifluoromethoxy-4-hydroxyquinoline-3-carboxylic acid ethyl ester; 4-Hydroxy-8-trifluoromethoxy-3-quinolinecarboxylic acid ethyl ester; 4-Hydroxy-8-trifluoromethoxyquinoline-3-carboxylic acid ethyl ester; 40516-39-0; Ethyl 4-hydroxy-8-(trifluoromethoxy)-3-quinolinecarboxylate; Quinoline-3-carboxylic acid, 4-hydroxy-8-(trifluoromethoxy)-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxy-8-Trifluoromethoxyquinoline-3-Carboxylic Acid Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured and controlled under a cGMP-compliant quality system suitable for pharmaceutical development. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting all release specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.