Description

1-Benzyl-Azetidine-2-Carboxylic Acid Amide is a high-purity, nitrogen-containing heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile chiral scaffold and intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and as a precursor for novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly protease inhibitors and other biologically active molecules.
• Medicinal Chemistry Research: Serves as a constrained scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Synthesis: Used as an intermediate in the development of new pesticides and herbicides with specific chiral requirements.
• Peptidomimetics: The azetidine core acts as a proline mimic or other amino acid surrogate in the design of peptide analogs with improved metabolic stability.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Useful for creating tool compounds and probes to study biological pathways and enzyme functions.

Basic Information

Product Name	1-Benzyl-Azetidine-2-Carboxylic Acid Amide
CAS No.	40432-40-4
Molecular Formula	C11H14N2O
Molecular Weight	190.24 g/mol
Synonyms	1-Benzylazetidine-2-carboxamide; (2S)-1-Benzylazetidine-2-carboxamide (if chiral); 2-Carbamoyl-1-benzylazetidine; Azetidine-2-carboxamide, 1-benzyl-; 1-Benzyl-2-azetidinecarboxamide; L-1-Benzylazetidine-2-carboxylic acid amide; BACA (abbreviation); Contact for details on specific stereoisomers.
EINECS	Contact for details

Quality Control

Our 1-Benzyl-Azetidine-2-Carboxylic Acid Amide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral purity (if applicable), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccant in the storage area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (if applicable)	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.