Description

2-Chloro-1-(Difluoromethoxy)-4-Nitro-Benzene is a specialized halogenated aromatic compound that serves as a critical building block in advanced chemical synthesis. Its unique molecular structure, featuring chloro, difluoromethoxy, and nitro substituents, makes it a valuable intermediate for creating complex molecules with tailored properties. This high-purity intermediate is essential for research and production in the pharmaceutical and agrochemical industries, where precise chemical functionality is paramount for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for compounds requiring difluoromethoxy and nitro aromatic motifs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where its halogenated structure contributes to biological activity and stability.
• Material Science Research: Employed in the creation of specialty polymers and liquid crystals, where the introduction of fluorine atoms can modify material properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions and nucleophilic aromatic substitutions to construct more complex, multi-functional aromatic systems.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing specialized azo dyes and pigments that benefit from the electron-withdrawing nitro group.

Basic Information

Item	Detail
Product Name	2-Chloro-1-(Difluoromethoxy)-4-Nitro-Benzene
CAS No.	40319-63-9
Molecular Formula	C7H4ClF2NO3
Molecular Weight	223.56 g/mol
Synonyms	2-Chloro-α,α-difluoro-4-nitroanisole; 1-Chloro-2-(difluoromethoxy)-5-nitrobenzene; 4-Nitro-2-chlorophenyl difluoromethyl ether; 2-Chloro-4-nitro-α,α-difluoroanisole; 2-Chloro-1-(difluoromethoxy)-4-nitrobenzene; 2-Chloro-4-nitro-1-(difluoromethoxy)benzene; 1-(Difluoromethoxy)-2-chloro-4-nitrobenzene
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-1-(Difluoromethoxy)-4-Nitro-Benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support customer audits to ensure full transparency and compliance with your quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.