Description

trans-4-Hydroxy-L-Proline Methyl Ester Hydrochloride is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other peptide mimetics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the constrained 4-hydroxyproline scaffold, which can influence peptide conformation and biological activity.
• Bioconjugation & Probe Development: Serves as a starting material for creating labeled probes or conjugates for biochemical and diagnostic applications.
• Chemical Biology Research: Employed in the study of collagen structure and function, as well as in the development of tools for glycobiology.
• Asymmetric Synthesis: Acts as a chiral auxiliary or precursor in stereoselective reactions to create enantiomerically pure compounds.

Basic Information

Product Name	trans-4-Hydroxy-L-Proline Methyl Ester Hydrochloride
CAS No.	40216-83-9
Molecular Formula	C₆H₁₁NO₃·HCl
Molecular Weight	181.62 g/mol (Free base: 145.16)
Synonyms	trans-4-Hydroxy-L-proline methyl ester HCl; L-4-Hydroxyproline methyl ester hydrochloride; Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride; HYP-OMe·HCl; 4-Hydroxy-L-proline methyl ester hydrochloride; (4R)-Hydroxy-L-proline methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our trans-4-Hydroxy-L-Proline Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing HPLC purity, specific rotation, and other critical parameters is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.