Description

(3R,4R)-4,5-Isopropylidene Pent-2-Yn-3-Ol CAS NO 4957-71-5 is a high-purity chiral building block featuring an isopropylidene-protected diol and an alkyne functionality. This compound matters as a versatile synthetic intermediate, enabling the stereoselective construction of complex molecular architectures in pharmaceutical and fine chemical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of prostaglandins, nucleoside analogs, and other bioactive molecules requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where the specific (3R,4R) configuration is critical for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral phosphine or N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products containing protected diol and alkyne motifs.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags via click chemistry reactions facilitated by the alkyne group.

Basic Information

Item	Details
Product Name	(3R,4R)-4,5-Isopropylidene Pent-2-Yn-3-Ol
CAS No.	4957-71-5
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	(3R,4R)-4,5-O-Isopropylidene-2-pentyn-1,4-diol; (3R,4R)-4,5-O-Isopropylidene-2-pentyne-1,4-diol; (3R,4R)-4,5-Isopropylidene-2-pentyn-1,4-diol; (3R,4R)-4,5-O-(1-Methylethylidene)-2-pentyn-1,4-diol; (3R,4R)-4,5-Isopropylidene-2-pentyne-1,4-diol; (3R,4R)-4,5-Isopropylidene-pent-2-yne-1,4-diol; (3R,4R)-4,5-Isopropylidene-2-pentyn-4-ol
EINECS	Contact for details

Quality Control

Our (3R,4R)-4,5-Isopropylidene Pent-2-Yn-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and cGMP standards where applicable. Comprehensive Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.