Description

N,o-Bis-(Benzyloxycarbonyl)-Hydroxylamine is a protected hydroxylamine derivative, widely utilized as a versatile building block in organic synthesis. Its primary value lies in its role as a key reagent for the controlled introduction of the hydroxylamine functional group, which is crucial for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in the development of active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various drug candidates, particularly those containing hydroxamic acid or N-oxide moieties.
• Peptide Synthesis: Used as a protecting group reagent for hydroxylamine during solid-phase and solution-phase peptide synthesis.
• Agrochemical Development: Serves as a key building block for creating novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Employed in the design and synthesis of probes for studying enzyme inhibition and protein function.
• Material Science Research: Used in the preparation of functional polymers and advanced materials requiring specific amine-oxide linkages.
• Cross-coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions to form C-N bonds.

Basic Information

Product Name	N,o-Bis-(Benzyloxycarbonyl)-Hydroxylamine
CAS No.	4950-01-0
Molecular Formula	C16H15NO5
Molecular Weight	301.29 g/mol
Synonyms	N,O-Bis(Cbz)-Hydroxylamine; N,O-Bis(benzyloxycarbonyl)hydroxylamine; N,O-Bis(Z)-Hydroxylamine; Hydroxylamine, N,N-bis(phenylmethoxy)carbonyl-; N,N-Bis(benzyloxycarbonyl)hydroxylamine; Di-Cbz-hydroxylamine; (Benzyloxycarbonyl)hydroxylamine, N,N-bis-; Z2NOH
EINECS	225-589-7

Quality Control

Our N,o-Bis-(Benzyloxycarbonyl)-Hydroxylamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.