Description

3-(Difluoromethoxy)Benzoic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its ability to introduce the difluoromethoxy group, a key structural motif that can enhance the metabolic stability and bioavailability of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the difluoromethoxy group contributes to improved efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Employed in the synthesis of specialized monomers and polymers for organic light-emitting diodes (OLEDs) and semiconductor materials.
• Chemical Research & Development: A versatile reagent for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and route scouting.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke fine chemicals and advanced intermediates.

Basic Information

Product Name	3-(Difluoromethoxy)Benzoic Acid
CAS No.	4837-19-8
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	3-(Difluoromethoxy)benzoic acid; Benzoic acid, 3-(difluoromethoxy)-; m-(Difluoromethoxy)benzoic Acid; 3-Difluoromethoxybenzoic acid; α,α-Difluoro-m-methoxybenzoic Acid; 3-Carboxy-α,α-difluoroanisole; DFMBA
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements of our global clientele. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.