Description

4-Chloro-2-Fluoro-5-Sulfamylbenzoic Acid is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its unique halogenated and sulfonamide-substituted benzoic acid structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of sulfonamide-based drug candidates, including diuretics, carbonic anhydrase inhibitors, and anti-cancer agents.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging its halogen and sulfamyl groups for bioactivity.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential intermediate for synthesizing functional polymers or ligands for metal-organic frameworks (MOFs) due to its carboxylic acid and sulfonamide functionalities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of proprietary compounds under cGMP or research-grade conditions.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-Sulfamylbenzoic Acid
CAS No.	4793-22-0
Molecular Formula	C7H5ClFNO4S
Molecular Weight	253.63 g/mol
Synonyms	5-Sulfamoyl-4-chloro-2-fluorobenzoic Acid; 4-Chloro-2-fluoro-5-sulfamoylbenzoic Acid; Benzoic acid, 4-chloro-2-fluoro-5-sulfamoyl-; 2-Fluoro-4-chloro-5-sulfamoylbenzoic Acid; 4-Chloro-2-fluoro-5-sulfamoyl-benzoic acid; 4793-22-0; 4-Chloro-2-fluoro-5-sulphamoylbenzoic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Sulfamylbenzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.