Description

5-Bromobenzo[C]Isoxazole is a high-purity brominated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile precursor for constructing complex molecular architectures, particularly in the development of pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Research: Used in the development of new generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the brominated isoxazole scaffold.
• Material Science Precursor: Acts as a building block for organic electronic materials, including organic light-emitting diodes (OLEDs) and charge-transport molecules.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Utilized in medicinal chemistry to create molecular probes for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form carbon-carbon bonds.

Basic Information

Product Name	5-Bromobenzo[C]Isoxazole
CAS No.	4682-91-1
Molecular Formula	C7H4BrNO
Molecular Weight	198.02 g/mol
Synonyms	5-Bromobenzisoxazole; 5-Bromo-1,2-benzisoxazole; 5-Bromo-1,2-benzoxazole; 5-Bromobenzo[d]isoxazole; Benzo[c]isoxazole, 5-bromo-; 4682-91-1; 5-Br-BI
EINECS	Contact for details

Quality Control

Our 5-Bromobenzo[C]Isoxazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<10 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.