Description

Boc-Pyr-Oh Dcha CAS NO 4677-75-2 is a high-purity, protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) protected form of 4-hydroxyproline complexed with dicyclohexylamine (DCHA). This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering enhanced solubility and handling characteristics for advanced research and manufacturing. It is primarily utilized by pharmaceutical R&D teams, process chemists, and fine chemical manufacturers engaged in the development of therapeutic peptides, prodrugs, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for introducing the 4-hydroxyproline residue into peptide chains under Boc-chemistry conditions.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) targeting collagen-related disorders and other therapeutic areas.
• Bioconjugation & Linker Chemistry: Used in the preparation of peptide-drug conjugates (PDCs) and other bioconjugates where the hydroxyl group provides a site for further functionalization.
• Research & Development: Essential for academic and industrial research in medicinal chemistry, biochemistry, and structural biology for studying protein structure and function.
• Process Development & Scale-Up: Employed in the development and optimization of scalable, GMP-compliant manufacturing processes for peptide therapeutics.

Basic Information

Product Name	Boc-Pyr-Oh Dcha
CAS No.	4677-75-2
Molecular Formula	C₁₆H₂₈N₂O₅ • C₁₂H₂₃N
Molecular Weight	428.51 (Free acid) / 553.75 (DCHA salt)
Synonyms	Boc-4-Hydroxy-L-proline Dicyclohexylamine Salt; (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic Acid DCHA Salt; Boc-Hyp-OH•DCHA; N-Boc-trans-4-Hydroxy-L-proline DCHA Salt; Nα-Boc-4-hydroxy-L-proline Dicyclohexylammonium Salt; tert-Butyloxycarbonyl-4-hydroxy-L-proline DCHA Salt; Boc-L-4-Hydroxyproline DCHA Complex
EINECS	Contact for details

Quality Control

Our Boc-Pyr-Oh Dcha is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-75.0° to -85.0° (c=1 in AcOH)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.