Description

1-Hydroxy-2,2,5,5-Tetramethylpyrrolidinium Chloride is a high-purity, functionalized pyrrolidine derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a versatile building block and intermediate, valued for its unique sterically hindered nitroxyl radical precursor structure. It is primarily sought after by research institutions, fine chemical manufacturers, and pharmaceutical developers working on novel drug candidates, spin-labeling agents, and polymerization catalysts.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nitroxide spin labels and probes used in Electron Paramagnetic Resonance (EPR) spectroscopy for studying biomolecular structure and dynamics.
• Polymer Chemistry: Acts as a stable nitroxide mediator in Nitroxide-Mediated Polymerization (NMP), a controlled radical polymerization technique for producing polymers with precise architecture.
• Organic Synthesis Building Block: Utilized in the preparation of complex heterocyclic compounds and as a source of the 1-hydroxy-2,2,5,5-tetramethylpyrrolidine moiety.
• Antioxidant Research: Investigated for its potential as a synthetic antioxidant or as a model compound in studying free radical scavenging mechanisms.
• Material Science: Used in the surface functionalization of materials and in the development of advanced coatings and composites.
• Analytical Chemistry: Employed as a standard or reagent in various spectroscopic and chromatographic analytical methods.

Basic Information

Product Name	1-Hydroxy-2,2,5,5-Tetramethylpyrrolidinium Chloride
CAS No.	4567-20-8
Molecular Formula	C9H20ClNO
Molecular Weight	193.71 g/mol
Synonyms	1-Hydroxy-2,2,5,5-tetramethylpyrrolidin-1-ium chloride; 2,2,5,5-Tetramethyl-1-pyrrolidinyloxy, hydrochloride; 1-Hydroxy-2,2,5,5-tetramethyl-δ1-pyrroline-N-oxyl hydrochloride; TEMPOL hydrochloride; 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl related analog; Hydroxyl-TEMPO hydrochloride; H-TEMPO HCl; Pyrrolidinium, 1-hydroxy-2,2,5,5-tetramethyl-, chloride
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-2,2,5,5-Tetramethylpyrrolidinium Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.