Description

H-Glu(Obzl)-Obzl Hcl is a protected glutamic acid derivative, specifically the dibenzyl ester hydrochloride salt. This compound is a crucial building block in peptide synthesis, offering selective protection for the γ-carboxyl group of glutamic acid. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptides and therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of glutamic acid residues.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing complex peptide sequences.
• Pharmaceutical Intermediate: Serves as a precursor in the research and production of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Useful for introducing glutamic acid motifs into larger biomolecules or drug delivery systems.
• Biochemical Research: Employed in studies of enzyme substrates, receptor ligands, and other bioactive peptides.
• Custom Peptide Service: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	H-Glu(Obzl)-Obzl Hcl
CAS No.	4561-10-8
Molecular Formula	C20H23NO4 • HCl
Molecular Weight	377.86 g/mol (Free base: 341.40 g/mol)
Synonyms	L-Glutamic acid α,γ-dibenzyl ester hydrochloride; H-Glu(OBzl)-OBzl•HCl; Dibenzyl L-glutamate hydrochloride; γ-Benzyl L-glutamate α-benzyl ester hydrochloride; Glutamic acid dibenzyl ester HCl; (S)-2-Amino-1,5-dibenzyloxy-1,5-dioxopentan-1-ium chloride; Benzyl (2S)-2-ammonio-4-(benzyloxy)-4-oxobutanoate chloride
EINECS	Contact for details

Quality Control

Our H-Glu(Obzl)-Obzl Hcl is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing specifications such as assay, chiral purity, and residual solvents is provided. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability. Keep the container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.