Description

(E)-2,2-Dimethyl-4-Phenyl-But-3-Enoic Acid is a high-purity, unsaturated carboxylic acid derivative characterized by its specific stereochemistry and phenyl-substituted structure. This compound serves as a versatile and valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the production of active pharmaceutical ingredients (APIs) and complex specialty molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Fine Chemical Synthesis: Used in the preparation of complex organic molecules, including fragrances, flavors, and advanced materials.
• Agrochemical Research: Acts as a precursor in the development of novel herbicides and plant growth regulators.
• Academic & Industrial R&D: Employed in methodological studies and catalysis research involving carbon-carbon bond formation and asymmetric synthesis.
• Ligand and Catalyst Development: The carboxylic acid functionality and rigid structure make it suitable for designing novel ligands for metal-catalyzed reactions.

Basic Information

Product Name	(E)-2,2-Dimethyl-4-Phenyl-But-3-Enoic Acid
CAS No.	4405-27-0
Molecular Formula	C12H14O2
Molecular Weight	190.24 g/mol
Synonyms	(E)-2,2-Dimethyl-4-phenyl-3-butenoic acid; (E)-3,3-Dimethyl-1-phenyl-1-buten-3-oic acid; trans-2,2-Dimethyl-4-phenyl-3-butenoic acid; α,α-Dimethyl-β-phenyl-trans-acrylic acid; 2,2-Dimethyl-4-phenyl-trans-crotonic acid; (E)-α,α-Dimethyl-β-phenylacrylic acid; β-Phenyl-trans-tiglic acid
EINECS	Contact for details

Quality Control

Our (E)-2,2-Dimethyl-4-Phenyl-But-3-Enoic Acid is manufactured under a strict quality management system. Each batch is subjected to rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and isomeric integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material is suitable for demanding applications in GMP-oriented synthesis and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isomeric Purity ((E)-isomer)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.