Description

L-Isoleucinol Hydrochloride is a high-purity chiral building block and intermediate of significant value in advanced organic synthesis. Its primary importance lies in its role as a precursor for the synthesis of complex pharmaceuticals, bioactive peptides, and specialized fine chemicals. This compound is essential for research institutions and industrial manufacturers focused on developing new active pharmaceutical ingredients (APIs), peptidomimetics, and other high-value nitrogen-containing compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and metabolic disease research.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce the isoleucinol moiety, modifying peptide backbone properties and bioactivity.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material for the preparation of enantiomerically pure compounds in medicinal chemistry.
• Bioconjugation & Linker Chemistry: Utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugates due to its amino and hydroxyl functional groups.
• Agrochemical Research: Employed as a building block for developing new chiral pesticides and herbicides with improved efficacy and selectivity.
• Material Science: A precursor for specialty polymers and dendrimers requiring specific chiral centers for advanced material properties.

Basic Information

Product Name	L-Isoleucinol Hydrochloride
CAS No.	4379-13-9
Molecular Formula	C6H15NO2 · HCl
Molecular Weight	169.65 g/mol (Free base: 133.19)
Synonyms	(2S,3S)-2-Amino-3-methylpentan-1-ol hydrochloride; L-Isoleucinol HCl; (S,S)-Isoleucinol hydrochloride; (2S,3S)-3-Methyl-2-aminopentanol hydrochloride; 1-Amino-2-methylbutane-3-ol hydrochloride (stereospecific); L-threo-Isoleucinol hydrochloride; L-β-Hydroxyisoleucine methyl ester derivative
EINECS	Contact for details

Quality Control

Our L-Isoleucinol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.