Description

2-Phenyl-2-Methyl-1,3-Dioxolane-4-Methanol is a versatile chiral building block and protected diol derivative, valued for its role in stereoselective organic synthesis. Its structure makes it a critical intermediate for constructing complex molecules in the pharmaceutical and fine chemical industries. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty polymers where precise stereochemistry is required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of various drug candidates, particularly in antiviral, cardiovascular, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of enantiomerically pure pesticides and herbicides, enhancing efficacy and reducing environmental impact.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and advanced materials requiring specific stereochemical configurations.
• Asymmetric Catalysis: Employed as a ligand or auxiliary in catalytic systems to induce chirality in reaction products.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialized polymers with unique thermal or mechanical properties.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research laboratories.

Basic Information

Item	Details
Product Name	2-Phenyl-2-Methyl-1,3-Dioxolane-4-Methanol
CAS No.	4361-60-8
Molecular Formula	C12H16O3
Molecular Weight	208.25 g/mol
Synonyms	4-(Hydroxymethyl)-2-phenyl-2-methyl-1,3-dioxolane; (4R)-2-Phenyl-2-methyl-1,3-dioxolane-4-methanol; (4S)-2-Phenyl-2-methyl-1,3-dioxolane-4-methanol; Phenylmethyl dioxolane methanol; Solketal phenyl derivative; 1,3-Dioxolane-4-methanol, 2-phenyl-2-methyl-; Benzaldehyde acetone ketal alcohol
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our chiral intermediates. Every batch of 2-Phenyl-2-Methyl-1,3-Dioxolane-4-Methanol is analyzed to ensure high chemical and enantiomeric purity, meeting the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC/GC), chiral purity, and impurity profiles are provided and available upon request. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer specified)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.