Description

2,2,4,4-Tetramethylcyclobutanone is a highly functionalized, sterically hindered cyclic ketone. This unique structure makes it a valuable and versatile building block in advanced organic synthesis and materials science. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for creating novel compounds with specific steric and electronic properties.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon or scaffold in the research and development of new active pharmaceutical ingredients (APIs), particularly for creating molecules with complex, three-dimensional architectures.
• Agrochemical Synthesis: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators where its hindered structure can influence biological activity and environmental stability.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Polymer & Material Science: Incorporated as a monomer or cross-linking agent to develop polymers with enhanced thermal stability, rigidity, or specific optical properties.
• Fragrance & Flavor Chemistry: Utilized in the synthesis of high-value aroma chemicals, leveraging its ketone functionality and unique steric profile to create novel scent molecules.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for studying steric effects, ring strain reactions, and developing new synthetic methodologies.

Basic Information

Product Name	2,2,4,4-Tetramethylcyclobutanone
CAS No.	4298-75-3
Molecular Formula	C8H14O
Molecular Weight	126.20 g/mol
Synonyms	2,2,4,4-Tetramethylcyclobutan-1-one; Tetramethylcyclobutanone; 1-Cyclobutanone, 2,2,4,4-tetramethyl-; NSC 163022
EINECS	Contact for details

Quality Control

Our 2,2,4,4-Tetramethylcyclobutanone is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A detailed Certificate of Analysis (COA) providing purity (typically by GC or HPLC), identity confirmation, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Research Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.