Description

tert-Butyl Carbamate is a versatile organic compound widely used as a key building block and protecting group in advanced chemical synthesis. Its primary value lies in its ability to introduce the tert-butoxycarbonyl (Boc) group, a cornerstone for protecting amine functionalities in peptide and pharmaceutical manufacturing. This makes it an essential intermediate for research institutions and industrial producers developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty organic compounds. The compound is valued for its stability under basic conditions and its clean deprotection under mild acidic conditions.

Application

• Pharmaceutical Intermediates: As a critical reagent for introducing the Boc protecting group in the synthesis of peptides, nucleotides, and complex drug molecules.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require protected amine intermediates.
• Organic Synthesis & Research: Serves as a fundamental building block in academic and industrial R&D for constructing novel heterocycles and complex organic structures.
• Peptide Chemistry: Essential for the stepwise solid-phase and solution-phase synthesis of peptides, ensuring regioselectivity and preventing side reactions.
• Polymer Science: Employed in the synthesis of specialized polyamides and polymers with specific functional group requirements.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	tert-Butyl Carbamate
CAS No.	4248-19-5
Molecular Formula	C5H11NO2
Molecular Weight	117.15 g/mol
Synonyms	Boc-NH2; tert-Butoxycarboxamide; Carbamic acid, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl carbamate; N-Boc-amine; N-(tert-Butoxycarbonyl)amine; t-Butyl carbamate; BOC-Amine
EINECS	224-214-6

Quality Control

Our tert-Butyl Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We can supply material compliant with various pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Melting Point	105 - 108 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.