Description

Colitose is a unique deoxy sugar, specifically 3,6-dideoxy-L-galactose, with the CAS registry number 4221-05-0. This compound is a critical biochemical building block, primarily valued for its role as a component of the O-antigen in the lipopolysaccharides of certain Gram-negative bacteria. It is essential for researchers and manufacturers in the fields of glycobiology, immunology, and vaccine development, where it is used to study bacterial pathogenesis and develop synthetic antigens or conjugate vaccines.

Application

• Glycobiology Research: A fundamental tool for studying bacterial cell surface polysaccharides, host-pathogen interactions, and immune recognition.
• Immunological Studies: Used in the synthesis of defined oligosaccharide antigens to investigate antibody responses and develop diagnostic assays.
• Vaccine Development: Serves as a key hapten or building block for the synthesis of conjugate vaccines targeting specific bacterial serotypes.
• Biochemical Synthesis: An intermediate in the chemoenzymatic synthesis of complex carbohydrates and glycoconjugates.
• Microbiology: Used to probe the biosynthesis and assembly of O-antigens in model organisms like Escherichia coli and Salmonella.
• Standards and Reference Materials: Provides a high-purity standard for analytical methods such as HPLC, GC-MS, and NMR in carbohydrate analysis.

Basic Information

Product Name	Colitose
CAS No.	4221-05-0
Molecular Formula	C6H12O4
Molecular Weight	148.16 g/mol
Synonyms	3,6-Dideoxy-L-galactose; D-Colitose; 3,6-Dideoxy-L-lyxo-hexose; Ascarylose; (-)-Colitose; L-Colitose; 3,6-Dideoxy-L-galactopyranose; Component of E. coli O111 and O55 B antigen
EINECS	224-173-9

Quality Control

Our Colitose is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP principles where applicable, and our analytical methods, including HPLC, NMR, and optical rotation, are validated to provide reliable specifications for the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under dry, inert conditions (e.g., in a desiccator) at a controlled room temperature (15-25°C). For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Optical Rotation	-30° to -35° (c=1 in H2O)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.