Description

1,4-Dioxaspiro[4.5]Dec-2-Ylmethanol is a versatile spirocyclic acetal-protected alcohol building block of significant importance in advanced organic synthesis. Its primary value lies in its role as a key chiral intermediate and protecting group precursor for carbonyl compounds, enabling the synthesis of complex molecules with high stereochemical control. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, specialized intermediates for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of prostaglandins, antiviral agents, and other bioactive molecules requiring precise stereochemistry.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the spiroacetal moiety contributes to biological activity and stability.
• Fine Chemical Production: Serves as a building block for fragrances, flavors, and functional materials that benefit from its rigid, bicyclic structure.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new catalytic asymmetric reactions.
• Polymer Chemistry: Can be utilized as a monomer or cross-linking agent for creating specialty polymers with unique thermal and mechanical properties.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in total synthesis and the exploration of new synthetic pathways.

Basic Information

Product Name	1,4-Dioxaspiro[4.5]Dec-2-Ylmethanol
CAS No.	4167-35-5
Molecular Formula	C10H18O3
Molecular Weight	186.25 g/mol
Synonyms	2-(Hydroxymethyl)-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decane-2-methanol; Spiro[1,3-dioxolane-2,1'-cyclohexane]-2-methanol; 2-(Hydroxymethyl)-1,4-dioxaspiro[4.5]decan; Cyclohexanone ethylene ketal-2-methanol
EINECS	Contact for details

Quality Control

Our 1,4-Dioxaspiro[4.5]Dec-2-Ylmethanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess (where applicable), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply and traceability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for high-purity grades. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (Optical Purity)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.